DOES, Inc. has some exciting inhaler news to share with you today. One of our powdered 
insulin inhalers has been shown in product development to be a top performer against other 
insulin inhaler products.  We have developed a new inhaler with many Positive Attributes:

DOES Powder Inhaler - Positive Attributes

1)    Delivers more powder to bottom (alveoli) of lungs

2)    Deposits very little drug dosage in the mouth

3)    In the throat - Deposits less drug dosage than other

  inhalers

4)    Easier for impaired breathers to use, an ‘Active 

  inhaler’

5)    May be used for dry powder, aerosols, and liquids

6)    Hand-held and self-administered

7)    Precise dosages can be delivered

8)    Tamper proof

9)    Uses disposable capsules

10)   Air-tight and waterproof

11)   Delivers sterile drug dosage

12)   Simple mechanism, long lasting

13)   Inexpensive to manufacture

14)   By changing capsules, may be used for several drugs

15)   May deliver two (or more) drugs simultaneously

16)   Does not use fluorocarbons

17)   Does not violate previous patents

18)   Small, compact, easy to carry

19)   Uses compressed air for power

20)   Easy to use

DOES Pipeline products 

1)      Device addition to Pfizer-Nektar Inhaler

DOES is developing an add-on device to improve the bio-availability of insulin to diabetics who use the Nektar-Pfizer Exubera inhaler. The Nektar inhaler gets only 10% efficiency when delivering inhaled insulin. The DOES addition is expected to increase efficiency to 40%. This will greatly reduce the cost of inhaled insulin. Inhaled insulin is now expected to cost three to four times injected insulin. Health insurance companies may not be willing to pay this increase in cost over injected insulin.  

      3)  Drug Vaporization device 

DOES is developing a handheld device to vaporize drugs into an aerosol for pulmonary delivery of certain pharmaceuticals. This device will produce very small particles. It is to be handheld, simple to make, and compact. We are investigating drugs that can be heated into a vaporized form.

  DOES background

The DOES staff has valuable experience in R&D device development. This experience has resulted in a large number of inhalation-related patents our staff has received for inhalation of small particles.

 

DOES, Inc. Staff – Number of Inhalation-Related Patents 

#1                             Over 100

#2                                        14 

#3                                          2

Total                        Over 116 Patents

 

Our scientists have a large base of experience in developing proven inhalation products and device development:

 DOES, Inc. Staff Experience in Inhalation Work  

                                            Scientist                      # of Years

#1                                41 

#2                                35 

#3                                31

Total                         107 Years Experience

 

DOES, Inc. Previous Product Development

a) Drug Delivery Device

• For Pulmonary Inhalation of small particles
• Health improvement product

b) Dry Powder Metal Alloy

• For a General Electric Aircraft motor
• With Allegheny-Teledyne-Allvac

c) System to predict F-16 Fighter Plane Flight   

     Parameters (Lift and Drag)

• For the F-16 Fighter Plane
• With Lockheed Martin Company

d) Certification and patenting of a metal alloy

• Copper Alloy number #6683
• For Federal Metal Company

e) Development of many other consumer products

• Del Monte food products
• Sara Lee textiles, Glidden Paint, Wrangler jeans
• Skoj (Swedish Fruit beverage)
• Archer Aluminum products

 f) NASA (National Aeronautics and Space Administration)

• Third and fourth Order Models
• Force Vector Calibration System (saves NASA $500,000. per calibration of Force Moment Balances) – developed by DOES and patented by NASA

 

DOES, Inc. Staff – Candy Product Development

 The DOES staff has completed major projects in developing candy products. These projects were to optimize the recipe and other design aspects of the following:

 

SNICKERS                #1 Best-selling Candy in the World

M&Ms                       #2 Candy in the World

Peanut

Chocolate

Milky Way

MARS Bars

TWIX

Baby Ruth

Skittles

 These were major projects with project costs from ranging from $200,000. each project to $1,100,000. for the biggest project. The goal of these projects was to optimize these products. These projects were done during the 1980s and helped the rise of these products to world-class sales achieved today.